As they rallied to defeat the Premier League's bottom team at St. Mary's, ten-man Wolves increased the pressure on Southampton manager Nathan Jones.
An hour after Mario Lemina received his second yellow card for disobedience and was dismissed from the game, January signing Joao Gomes scored the game-winning goal on his debut for Julen Lopetegui's team.
Before Lemina was dismissed, Carlos Alcaraz had given the struggling home team the lead, but the Saints were unable to increase their advantage against resolute opposition in front of a worried home crowd.
After 72 minutes, Wolves' perseverance paid off when Jan Bednarek unintentionally bundled the ball over the goal line after blocking Adama Traore's shot.
As Gomes scored to complete a remarkable turnaround, the atmosphere among the home crowd deteriorated, and the full-time whistle was met with a chorus of jeers.
The loss moved Wolves up to 15th place and five points above the relegation zone, while Southampton fell to fourth place and four points from safety. .
Jones is at risk after a disastrous defeat.
Both Lopetegui and Jones were appointed to their positions during the same week in November, but three months later, their circumstances could not be more dissimilar.
Wolves' point total has more than doubled under former Real Madrid manager Lopetegui after seven Premier League games, while rock-bottom Southampton has now dropped seven of its last eight games under Jones.
The visiting Saints supporters were vocal about their displeasure as they watched their team lose to Brentford last weekend, with the away section yelling, "Nathan Jones, get out of our club.".
With his poorly received post-match remarks, Jones only served to exacerbate the unrest, even though he insisted this week that he had been taking responsibility rather than deflecting blame for the team's poor performance.
It will be interesting to see if Jones can survive this latest setback after losing this game in the circumstances, having led with a man advantage at halftime.
As they watched their team crumble in the final 20 minutes to tie the worst home league run in the club's history, the Saints supporters had every right to express their annoyance once more in their own backyard.
Contrastingly, this Wolves team is starting to make clear progress under Lopetegui, and this remarkable comeback resulted in consecutive league victories for the first time since March 2022.
Wolves dig in to eke out an existence in peril.
A dramatic three-minute span in the first half appeared to have given Jones the ideal afternoon.
On his first league appearance for the team, 20-year-old Argentine Alcaraz scored, cheering up the home crowd with his reactive finish that deflected off the post.
After receiving a warning for a foul on Alcaraz after nine minutes, Lemina ran towards referee Jarred Gillett while calls for a penalty were being made.
To Wolves' credit, the guests never gave the hosts a chance to relax as they put in endless effort to make up for their smaller number.
After Bednarek's unfortunate own goal, Lopetegui's team consistently looked the more likely to continue the game and win it, attempting nine shots to Southampton's five in the second half.
Three minutes from time, substitute Gomes' beautiful side-footed goal sealed a remarkable victory, and Wolves can further distance themselves from trouble when they play Bournemouth the following weekend.
The impressive performance by 20-year-old club record signing Kamaldeen Sulemana, who displayed his pace, trickery, and willingness to shoot in a promising full debut, was the only reason for optimism on a very discouraging day for Southampton.
